abbr. SJ GMU
ISSN 2657-5841 (printed)
ISSN 2657-6988 (online)
DOI: 10.26408
Conjugated Linoleic Acid and the Atherosclerosis in Animal Models – Review
Conjugated linoleic acid (CLA) refers to a group of isomeric forms of linoleic acid (LA) containing two conjugated sites of unsaturation. During last 20 years, CLA has been the subject of investigations considered on its possible benefits on health. Both CLA isomers are found in products from ruminants because of the action of rumen micro-organisms in fatty acid biohydrogenation. The purpose of this review is to underline the potential for cis-9, trans-11 and trans-10, cis-12 CLA to modify atherosclerosis, with focus on the rabbit, hamster and the mouse examples.
Arbonés-Mainar J.M., Nawarro M.A., Guzman M.A., Arnal C., Surra J.C., Carnicer R., Osada J., Roche H.M., 2006, Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoproteiny E knockout mice, Atherosclerosis, 189, 318–327.
Bhattacharya A., Banu J., Rahman M., Causey J., Fernandes G., 2006, Biological effects of conjugated linoleic acids in health and disease, Journal of Nutritional Biochemistry, 17, 789–810.
Chamruspollert, M., Sell, J.L., 1999, Transfer of dietary conjugated linoleic acid to egg yolks of chickens. Poultry Sci. 78, 1138–1150.
Chin, S.F., Liu, W., Storkson, J.M., Ha, Y.L., Pariza, M.W., 1992. Dietary sources of conjugated dienoic derivatives of linoleic acid, a newly recognized class of anticarcinogens, J. Food Compos. Anal., 5, 185–197.
Chouinard, P.Y., Corneau, L., Butler, W.R., Chilliard, Y., Drackley, J.K., Bauman, D.E., 2001, Effect of dietary lipid source on conjugated linoleic acid concentrations in milk fat, J. Dairy Sci.84, 680–690.
Cooper M.H., Miller J.R., Mitchell P.L., Currie D.L., McLeod R.S., 2008, Conjugated linoleic acid isomers have no effect on atherosclerosis and adverse effects on lipoprotein and liver lipid metabolism in apoE-/- mice fed a high cholesterol diet, Atherosclerosis, 200, 294–302.
Dhiman T.R., Olson K.C., MacQueen I.S., Pariza M.W., 1999, Conjugated linoleic acid content of meat from steers fed soybean oil, J. Dairy Sci., (Suppl. 1), 84.
Franczyk-Żarów M., Janczy A., 2011, Wpływ izomeru sprzężonego kwasu linolowego cis-9, trans-11 na rozwój zmian miażdżycowych u myszy genetycznie zmodyfikowanych ApoE/LDLr-/-, Praca magisterska wykonana we współpracy z Uniwersytetem Rolniczym w Krakowie.
Kelly G.S., 2001, Conjugated linoleic acid: a review. Alternative Medicine Review, 6(4), 367–382.
Kramer J.K.G., Sehat N., Dugan M.E.R., Mossob M.M., Yurawecz M.P., Roach J.A.G., Eulitz K., Aalhus J.L., Schaefer A.L., Ku Y., 1998, Distributions of conjugated linoleic acid (CLA) isomers in tissue lipid classes of pigs fed a commercial CLA mixture determined by gas chromatography and silver ion-high-performance liquid chromatography, Lipids 33, 549–558.
Kritchevsky D., Tepper S.A., Wright S., Czarnecki S.K., Tso P., 2000, Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits, J. Am. Coll. Nutr., 19, 427S–477S.
Lee KN., Kritchevsky D., Pariza MW., 1994, Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis, 108, 19–25.
Mitchell P.L., Langille M.A., Currie D.L., McLeod R.S., 2005, Effect of conjugated linoleic acid isomers on lipoproteins and atherosclerosis in the Syrian Golden hamsters. Biochemica et Biophysica Acta, 1734, 269-276.
Mitchell P., McLeod R., 2008, Conjugated linoleic acid and atherosclerosis: studies in animal models, Biochem. Cell Biol., 86, 293–301.
Nakamura Y., Flintoff-Dye N., T Omaye S., 2008, Conjugated linoleic acid modulation of risk factors associated with atherosclerosis, Nutrition and Metabolism, 5:22, 1–20.
Park Y., Pariza M.W. 2007, Mechanism of body fat modulation by conjugated linoleic acid (CLA), Food Research International, 40, 311–323.
Schmid A., Collomb M., Sieber R., Bee G., 2006, Conjugated linoleic acid in meat and meat products: a review, Meat Science, 73, 29–41.
Toomey S., Harhen B., Roche H.M., Fitzgerald D., Belton O., 2006, Profound resolution of early atherosclerosis with conjugated linoleic acid. Atherosclerosis, 187, 40–49.
Valeille K., Ferezou J., Quignard-Buolange A., Amsler G., Parguet M., Gripois D., Dorovska-Taran V., Martin J.C., 2005, A cis-9, trans-11 conjugated linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster, Am. J. Physiol. Heart Circ. Physiol., 289, H652-H659.
Valeille K., Ferezou J., Quignard-Buolange A., Amsler G., Parguet M., Gripois D., Dorovska-Taran V., Martin J.C., 2006, The natural concentration of the conjugated linoleic acid cis-9, trans-11 in milk fat has antiatherogenic effects in hiperlipidemic hamsters, J. Nutr., 136. 1305–1310.
Wahle K., Heys S., Rotondo D., 2004, Conjugated linoleic acids: are they beneficial or determental to health? Progress in Lipid Research, 43, 553–587.
Wilson T., Saati A., Kotyla T., Kritchevsky D., 2006, Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters, Lipids 41, 41–48.